Add pretzel twists and peanuts to a food processor and pulse until the largest chunks are about 1/8" wide. Add melted butter and pulse for another 3-5 seconds until butter is incorporated.
Spoon pretzel crust into the bottom of 4 serving jars and press into the bottom of the jar. Set aside.
Add yogurt, cream cheese, peanut butter, and vanilla extract to a mixing bowl, then add protein powder and PB2. Mix with a hand mixer until smooth, then scoop into a piping bag.
Pipe the cheesecake mixture into the serving cups on top of the pretzel crust. Top with optional toppings before serving, if desired.